Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging.
Yonsei Med J
; 65(2): 55-69, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38288646
ABSTRACT
Mitochondria function as platforms for bioenergetics, nutrient metabolism, intracellular signaling, innate immunity regulators, and modulators of stem cell activity. Thus, the decline in mitochondrial functions causes or correlates with diabetes mellitus and many aging-related diseases. Upon stress or damage, the mitochondria elicit a series of adaptive responses to overcome stress and restore their structural integrity and functional homeostasis. These adaptive responses to low-level or transient mitochondrial stress promote health and resilience to upcoming stress. Beneficial effects of low-grade mitochondrial stress, termed mitohormesis, have been observed in various organisms, including mammals. Accumulated evidence indicates that treatments boosting mitohormesis have therapeutic potential in various human diseases accompanied by mitochondrial stress. Here, we review multiple cellular signaling pathways and interorgan communication mechanisms through which mitochondrial stress leads to advantageous outcomes. We also discuss the relevance of mitohormesis in obesity, diabetes, metabolic liver disease, aging, and exercise.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Promoção da Saúde
/
Doenças Metabólicas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Yonsei Med J
Ano de publicação:
2024
Tipo de documento:
Article