Immune checkpoint inhibitors in liver transplantation: Current practice, challenges, and opportunities.
Liver Transpl
; 30(7): 742-752, 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38345379
ABSTRACT
Immune checkpoint inhibitors are becoming a mainstay of cancer treatment. While first studied and approved for patients with unresectable disease, due to their efficacy, they are becoming increasingly used in the perioperative period across many cancer types. In patients with HCC, immune checkpoint inhibitors have now become the standard of care in the advanced setting and have shown promising results in the adjuvant setting after liver resection. While these drugs continue to show promise, their role in the peritransplant setting still remains a question. In this review, we explore the current use of this class of medications in patients with HCC, as well as the immunologic role of the pathways that they inhibit. We also identify potential for future research opportunities to better understand the role of these medications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Fígado
/
Carcinoma Hepatocelular
/
Inibidores de Checkpoint Imunológico
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Revista:
Liver Transpl
/
Liver transplant. (Print)
/
Liver transplantation (Online)
Assunto da revista:
GASTROENTEROLOGIA
/
TRANSPLANTE
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos