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Relationship in development of malocclusions to polymorphisms of selected vitamin D receptors.
Dominiak, Marzena; Leszczyszyn, Anna; Laczmanska, Izabela; Machoy, Monika; Gerber, Hanna; Choukroun, Joseph; Gedrange, Tomasz; Hnitecka, Sylwia.
Afiliação
  • Dominiak M; Department of Dental Surgery, Wroclaw Medical University, Poland.
  • Leszczyszyn A; Department of Dental Surgery, Wroclaw Medical University, Poland.
  • Laczmanska I; Department of Genetics, Wroclaw Medical University, Poland.
  • Machoy M; Department of Orthodontics, Pomeranian Medical University, Szczecin, Poland.
  • Gerber H; Department of Maxillofacial Surgery, Wroclaw Medical University, Poland.
  • Choukroun J; Private Pain Clinic, Nice, France.
  • Gedrange T; Department of Orthodontics, Technische Universität Dresden, Germany.
  • Hnitecka S; Department of Maxillofacial Surgery, Wroclaw Medical University, Poland.
Adv Clin Exp Med ; 33(6): 601-608, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38353502
ABSTRACT

BACKGROUND:

The development of malocclusion is related to various factor, many of which are still not fully explained. The steroid hormone, 1,25-dihydroxyvitamin D3, has pleiotropic effects. It plays a key role in skeletal metabolism and the control of cell repair by attaching to the nuclear vitamin D steroid receptor (VDR). This vitamin affects bone turnover through the processes of bone tissue formation and resorption via its action on cells of the osteoblastic and osteoclastic lineage, exerts a modulating effect on the immune system, and is involved in the regulation of cell proliferation and differentiation. The role of vitamin D3 (VD3) and its receptor polymorphisms is a rarely studied topic in dentistry. Due to the proven influence on bone turnover processes and immune responses, the main research topic is its relation to periodontal diseases, but so far, its role in the formation and development of malocclusions has not been assessed.

OBJECTIVES:

This study aimed to assess the association of selected VDR polymorphisms Cdx2 (rs11658820), TaqI (rs7975232), BsmI (rs1544410), ApaI (rs7975232), and FokI (rs2228570) with the development of malocclusions. MATERIAL AND

METHODS:

A prospective observational study was performed. The examination consisted of a medical interview, intraand extraoral orthodontic diagnosis, alginate impression, cone beam computed tomography (CBCT), and venous blood sample to obtain genomic DNA and assess VDR polymorphisms.

RESULTS:

The rs11658820 polymorphism causes an almost 4-fold increase in the probability of the presence of a malocclusion. GT and TT genotypes of rs7975232 are also associated with a similar risk - almost 6 and almost 5 times higher, respectively. In turn, the effect of the rs2228570-AG and GG genotype polymorphisms on the occurrence of transversal anomalies was demonstrated (odds ratio (OR) = 8.46 and OR = 6.92, respectively).

CONCLUSIONS:

The association of individual polymorphisms with specific malocclusions should be carefully assessed, especially since some trends have been indicated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Calcitriol / Predisposição Genética para Doença / Má Oclusão Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Adv Clin Exp Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Polônia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Calcitriol / Predisposição Genética para Doença / Má Oclusão Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Adv Clin Exp Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Polônia