Exploring membrane asymmetry and its effects on membrane proteins.
Trends Biochem Sci
; 49(4): 333-345, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38355393
ABSTRACT
Plasma membranes utilize free energy to maintain highly asymmetric, non-equilibrium distributions of lipids and proteins between their two leaflets. In this review we discuss recent progress in quantitative research enabled by using compositionally controlled asymmetric model membranes. Both experimental and computational studies have shed light on the nuanced mechanisms that govern the structural and dynamic coupling between compositionally distinct bilayer leaflets. This coupling can increase the membrane bending rigidity and induce order - or lipid domains - across the membrane. Furthermore, emerging evidence indicates that integral membrane proteins not only respond to asymmetric lipid distributions but also exhibit intriguing asymmetric properties themselves. We propose strategies to advance experimental research, aiming for a deeper, quantitative understanding of membrane asymmetry, which carries profound implications for cellular physiology.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bicamadas Lipídicas
/
Proteínas de Membrana
Idioma:
En
Revista:
Trends Biochem Sci
/
Trends biochem. sci
/
Trends in biochemical sciences
Ano de publicação:
2024
Tipo de documento:
Article