The association between per-/polyfluoroalkyl substances in serum and thyroid function parameters: A cross-sectional study on teenagers living near a Chinese fluorochemical industrial plant.
Sci Total Environ
; 920: 170985, 2024 Apr 10.
Article
em En
| MEDLINE
| ID: mdl-38367719
ABSTRACT
Thyroid hormones (THs) play an important role in a wide range of crucial biological functions related to growth and development, and thyroid antibodies (TAs) can influence the biosynthesis of THs. Epidemiological studies have indicated that per- and polyfluoroalkyl substances (PFAS) could induce thyroid disruption, but studies on teenagers living in areas with high PFAS exposure are limited. This cross-sectional study focused on 836 teenagers (11- 15 years) living near a Chinese fluorochemical industrial plant. Decreased levels of free thyroxine (FT4, ﹤9.6 pmol/L, abnormal rate = 19.0 %) and elevated levels of free triiodothyronine (FT3, ï¹¥6.15 pmol/L, abnormal rate = 29.8 %) were observed. Correlations of serum PFAS concentrations and TAs/THs were analyzed. Increased PFOA was identified as a risk factor of decreased FT4 by using unadjusted (OR 11.346; 95 % CI 6.029, 21.352, p < 0.001) and adjusted (OR 12.566; 95 % CI 6.549, 24.115, p < 0.001) logistic regression models. In addition, significantly negative correlations were found between log10 transformed PFOA and FT4 levels using linear (unadjusted ß = -1.543, 95 % CI -1.937, -1.148, p < 0.001; adjusted ß = -1.534, 95 % CI -1.930, -1.137, p < 0.001) and BKMR models. For abnormal FT3, a significantly positive association between PFHxS and FT3 levels was observed in a regression model (unadjusted ß = -0.903, 95 % CI -1.212, -0.595, p < 0.001; adjusted ß = -0.894, 95 % CI -1.204, -0.583, p < 0.001), and PFHxS was identified as a risk factor (unadjusted OR 4.387; 95 % CI 2.619, 7.346, p < 0.001; adjusted OR 4.527; 95 % CI 2.665, 7.688, p < 0.001). Sensitivity analyses confirmed the robustness of the above results. This study reported the elevated PFAS exposure and thyroid function of teenagers living near a fluorochemical industrial plant from China.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes Ambientais
/
Fluorocarbonos
Limite:
Adolescent
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Sci Total Environ
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China