Boron Trifluoride-Mediated Domino Dehydration/Electrophilic Cyclization of Silylalkynols Leading to 2,3-Fused Tricyclic Benzofulvenes.

Okitsu, Takashi; Yoshikawa, Takeshi; Morohashi, Mai; Aoki, Kokoro; Yakura, Takayuki; Sakata, Ken; Hatano, Manabu

Okitsu, Takashi; Yoshikawa, Takeshi; Morohashi, Mai; Aoki, Kokoro; Yakura, Takayuki; Sakata, Ken; Hatano, Manabu.

Afiliação

Okitsu T; Faculty of Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan.
Yoshikawa T; Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
Morohashi M; Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Kobe 658-8558, Japan.
Aoki K; Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
Yakura T; Faculty of Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan.
Sakata K; Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
Hatano M; Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Kobe 658-8558, Japan.

Org Lett ; 2024 Feb 22.

Article em En | MEDLINE | ID: mdl-38385717

ABSTRACT

ABSTRACT

A BF3-mediated domino dehydration/electrophilic cyclization of silylalkynols to form 2,3-fused tricyclic benzofulvenes was achieved. In the latter step, in situ generated BF3·OH2 enables the electrophilic activation of alkynes. The predominant Z-selectivity of the reaction is also discussed.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

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