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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A*3303 and HLA-DPB1*0501.
Shu, Yaqing; Huang, Renliang; Li, Qihui; Lu, Yi; Yin, Junping; Li, Huilu; Lan, Zhike; Zheng, Xiujun; Ye, Jinlong; Long, Youming; Wang, Zhanhang; Xiao, Li; Zhou, Qiaomiao; Liu, Xu; Fu, Ying; Chen, Hao; Chen, Juanjuan; Zhou, Yanxia; Zhou, Juan; Zhang, Liting; Zhou, Jing; Jiang, Ying; Peng, Fuhua; Lu, Zhengqi; Petersen, Frank; Qiu, Wei; Yu, Xinhua.
Afiliação
  • Shu Y; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Huang R; Department of Genetics and Prenatal Diagnosis, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
  • Li Q; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Lu Y; Department of Neurology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Yin J; Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn, Germany.
  • Li H; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Lan Z; Department of Neurology, GuangDong 999 Brain Hospital, Guangzhou, China.
  • Zheng X; Department of Neurology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, China.
  • Ye J; Department of Neurology, GuangDong 999 Brain Hospital, Guangzhou, China.
  • Long Y; Department of Neurology, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Wang Z; Department of Neurology, GuangDong 999 Brain Hospital, Guangzhou, China.
  • Xiao L; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Zhou Q; Department of Genetics and Prenatal Diagnosis, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
  • Liu X; Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
  • Fu Y; Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Chen H; Department of Neurology, The First Affiliated Hospital Nanchang University, Nanchang, China.
  • Chen J; Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China.
  • Zhou Y; Department of Neurology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
  • Zhou J; Department of Neurology, Chenzhou First People's Hospital, Chenzhou, China.
  • Zhang L; Department of Neurology, Jiangxi Chest Hospital, Jiangxi, China.
  • Zhou J; Department of Neurology, Foshan First People's Hospital, Foshan, China.
  • Jiang Y; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Peng F; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Lu Z; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Petersen F; Division of Pulmonary Immune Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel, Borstel, Germany.
  • Qiu W; Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Yu X; Department of Genetics and Prenatal Diagnosis, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
Ann Neurol ; 95(5): 901-906, 2024 May.
Article em En | MEDLINE | ID: mdl-38400794
ABSTRACT
We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA-A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32-3.06, p = 0.00072, padj. = 0.046) and HLA-DBP1*0501 (OR = 0.51, 95% CI = 0.36-0.71, p = 0.000048, padj. = 0.0062). Moreover, HLA-A*3303 carriers with the disease had a longer hospital stay (p = 0.0005) than non-carriers. This study for the first time provides evidence for a role of genetic factor in the development of autoimmune GFAP astrocytopathy. ANN NEUROL 2024;95901-906.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-A / Astrócitos / Cadeias beta de HLA-DP / Proteína Glial Fibrilar Ácida Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-A / Astrócitos / Cadeias beta de HLA-DP / Proteína Glial Fibrilar Ácida Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China