Neural tube defects and epigenetics: role of histone post-translational histone modifications.
Epigenomics
; 16(6): 419-426, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38410929
ABSTRACT
Neural tube defects (NTDs) are the most common congenital anomalies of the CNS. It is widely appreciated that both genetic and environmental factors contribute to their etiology. The inability to ascribe clear genetic patterns of inheritance to various NTD phenotypes suggests it is possible that epigenetic mechanisms are involved in the etiology of NTDs. In this context, the contribution of DNA methylation as an underlying contributing factor to the etiology of NTDs has been extensively reviewed. Here, an updated accounting of the evidence linking post-translational histone modifications to these birth defects, relying heavily upon studies in humans, and the possible molecular implications inferred from reports based on cellular and animal models, are presented.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Defeitos do Tubo Neural
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Chile