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Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.
Lai, Ruo-Yah; Rummey, Christian; Amlang, Christian J; Lin, Chi-Ying R; Chen, Tiffany X; Perlman, Susan; Wilmot, George; Gomez, Christopher M; Schmahmann, Jeremy D; Paulson, Henry; Ying, Sarah H; Onyike, Chiadi U; Zesiewicz, Theresa A; Bushara, Khalaf O; Geschwind, Michael D; Figueroa, Karla P; Pulst, Stefan M; Subramony, Sub H; Burns, Matthew R; Opal, Puneet; Duquette, Antoine; Ashizawa, Tetsuo; Hamedani, Ali G; Davis, Marie Y; Srinivasan, Sharan R; Moore, Lauren R; Shakkottai, Vikram G; Rosenthal, Liana S; Kuo, Sheng-Han.
Afiliação
  • Lai RY; Department of Neurology, Columbia University Medical Center, New York, New York, USA.
  • Rummey C; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, New York, USA.
  • Amlang CJ; Clinical Data Science, Basel, Switzerland.
  • Lin CR; Department of Neurology, Columbia University Medical Center, New York, New York, USA.
  • Chen TX; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, New York, USA.
  • Perlman S; Department of Neurology, SUNY Downstate Health Sciences University, Brooklyn, New York, New York, USA.
  • Wilmot G; Alzheimer's Disease and Parkinson's Disease Centers, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
  • Gomez CM; Department of Neurology, Columbia University Medical Center, New York, New York, USA.
  • Schmahmann JD; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, New York, USA.
  • Paulson H; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Ying SH; Department of Neurology, University of California Los Angeles, Los Angeles, California, USA.
  • Onyike CU; Department of Neurology, Emory University, Atlanta, Georgia, USA.
  • Zesiewicz TA; Department of Neurology, University of Chicago, Chicago, Illinois, USA.
  • Bushara KO; Ataxia Center, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Geschwind MD; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
  • Figueroa KP; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
  • Pulst SM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
  • Subramony SH; Department of Neurology, University of South Florida, Tampa, Florida, USA.
  • Burns MR; Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Opal P; Department of Neurology, University of California San Francisco, San Francisco, California, USA.
  • Duquette A; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Ashizawa T; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.
  • Hamedani AG; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
  • Davis MY; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
  • Srinivasan SR; Department of Neurology, Northwestern University, Chicago, Illinois, USA.
  • Moore LR; Centre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, Quebec, Canada.
  • Shakkottai VG; Houston Methodist Research Institute, Houston, Texas, USA.
  • Rosenthal LS; Departments of Neurology, Ophthalmology, and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kuo SH; Department of Neurology, University of Washington, Seattle, Washington, USA.
Mov Disord Clin Pract ; 11(5): 496-503, 2024 May.
Article em En | MEDLINE | ID: mdl-38419568
ABSTRACT

BACKGROUND:

Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.

OBJECTIVES:

To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.

METHODS:

Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life.

RESULTS:

Fatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA.

CONCLUSIONS:

Fatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Ataxias Espinocerebelares / Fadiga Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mov Disord Clin Pract Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Ataxias Espinocerebelares / Fadiga Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mov Disord Clin Pract Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos