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Estimated median density identifies donor age and sex differences in red blood cell biological age.
Mykhailova, Olga; Brandon-Coatham, Mackenzie; Durand, Kiarra; Olafson, Carly; Xu, April; Yi, Qi-Long; Kanias, Tamir; Acker, Jason P.
Afiliação
  • Mykhailova O; Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada.
  • Brandon-Coatham M; Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada.
  • Durand K; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
  • Olafson C; Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada.
  • Xu A; Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada.
  • Yi QL; Canadian Blood Services, Ottawa, Ontario, Canada.
  • Kanias T; Vitalant Research Institute, Denver, Colorado, USA.
  • Acker JP; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Transfusion ; 64(4): 705-715, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38420746
ABSTRACT

BACKGROUND:

Donors possess heterogeneous red cell concentrates (RCCs) in terms of the biological age of their red blood cells (RBCs) as a direct result of various donor-dependent factors influencing rates of erythropoiesis. This study aimed to estimate the median biological age of RBCs in RCCs based on donor age and sex to investigate inherent differences in blood products' biological ages over hypothermic storage using estimated median densities (EMDs). STUDY

DESIGN:

Sixty RCCs were collected from four donor groups; male and female teenagers (17-19 years old) and seniors (75+ years old). A Percoll density-based separation approach was used to quantify the EMDs indicative of biological age. EMD and mean corpuscular hemoglobin (MCHC) were compared by correlation analyses.

RESULTS:

Differences in the median biological age of RCC units were observed with male donors having significantly higher EMDs compared to females (p < .001). Teen male donors possessed the highest EMDs with significantly elevated levels of biologically aged RBCs compared to both female donor groups, regardless of storage duration (p < .05). Throughout most of the 42-day storage period, senior donors, particularly senior females, demonstrated the strongest correlation between EMD and MCHC (R2 > 0.5).

CONCLUSIONS:

This study provides further evidence that there are inherent differences between the biological age profiles of RBCs between blood donors of different sex and age. Our findings further highlight that biological age may contribute to RBC quality during storage and that donor characteristics need to be considered when evaluating transfusion safety and efficacy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Eritrócitos Limite: Adolescent / Adult / Aged / Female / Humans / Male Idioma: En Revista: Transfusion Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Eritrócitos Limite: Adolescent / Adult / Aged / Female / Humans / Male Idioma: En Revista: Transfusion Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá