Effects of calcitonin on lumbar spinal stenosis.
Arch Orthop Trauma Surg
; 144(5): 1889-1900, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38436716
ABSTRACT
STUDY DESIGN:
Systematic review and meta-analysis.OBJECTIVE:
There is some controversy about the effects of calcitonin (CT) on lumbar spinal stenosis (LSS). This systematic review and meta-analysis is to assess the strength of the evidence supporting the use of CT in the treatment of patients with LSS. MATERIAL ANDMETHOD:
We performed an electronic search depicting randomized controlled trials (RCTs) through 4 databases from the date of database creation to January 2023. 3 different researchers conducted independent literature screening, data extractions, and quality assessments. The outcome measures included visual analogue scale (VAS), walking distance, and oswestry disability index (ODI). Meta-analysis and trial sequence analysis (TSA) were carried out using RevMan 5.4, Stata 16.0, and TSA 0.9. GRADE 3.6 was used to evaluate the evidence quality.RESULTS:
We accepted 9 studies with 496 participants. The meta-analysis revealed that CT offered no significant improvement in VAS, walking distance, or ODI in patients with LSS.CONCLUSION:
There is no evidence that CT has a benefit in patients with LSS, either alone or in combination with other treatments, or depending on the route of administration, according to the systematic review and meta-analysis of relevant RCTs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estenose Espinal
/
Calcitonina
/
Vértebras Lombares
Limite:
Humans
Idioma:
En
Revista:
Arch Orthop Trauma Surg
/
Arch. orthop. trauma surg
/
Archives of orthopaedic and trauma surgery
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China