Enantioseparation via Chiral Supramolecular Gels Comprising Ambidextrous Gelators Based on ß-Peptide-type Primary Amines.
Chempluschem
; 89(8): e202400021, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38445837
ABSTRACT
While ß-peptides have been paid attention due to their diverse secondary structures, their application to the design of low-molecular-weight gelators (LMWGs) is less explored. In this work, chiral cyclic ß-amino acid-based ß-peptides were developed as ambidextrous LMWGs, wherein multiple hydrogen bonds between the amide moieties led to high gelation ability. Their molecular assembly was elucidated using spectroscopies, microscopy, and X-ray analysis. Further, the supramolecular gel was used as a platform for the enantioselective extraction of (S)-naproxen from its racemate under optimized conditions. These findings have expanded the utility of ß-peptides and shown the potential of supramolecular gels as a distinct dynamic medium for enantiomer separation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminas
/
Géis
Idioma:
En
Revista:
Chempluschem
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão