Limited dsRNA editing impedes leukemia stem cells.
Trends Cancer
; 10(4): 280-282, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38458943
ABSTRACT
Understanding the mechanisms underlying the generation and maintenance of leukemia stem cells (LSCs) is crucial for the development of effective therapies against T cell acute lymphoblastic leukemia (T-ALL). In a recent study, Rivera et al. discovered that elevated adenosine deaminase acting on RNA (ADAR)-1-mediated RNA editing is a distinguishing feature of T-ALL relapse, and that ADAR1 suppresses apoptosis triggered by the double-stranded (ds)RNA-sensing pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia-Linfoma Linfoblástico de Células T Precursoras
Limite:
Humans
Idioma:
En
Revista:
Trends Cancer
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos