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Clinical, Biomarker, and Research Tests Among US Government Personnel and Their Family Members Involved in Anomalous Health Incidents.
Chan, Leighton; Hallett, Mark; Zalewski, Chris K; Brewer, Carmen C; Zampieri, Cris; Hoa, Michael; Lippa, Sara M; Fitzgibbon, Edmond; French, Louis M; Moses, Anita D; van der Merwe, André J; Pierpaoli, Carlo; Turtzo, L Christine; Yonter, Simge; Shahim, Pashtun; Moore, Brian; Stamps, Lauren; Flynn, Spencer; Fontana, Julia; Tata, Swathi; Lo, Jessica; Fernandez, Mirella A; Joseph, Annie-Lori; Matsubara, Jesse; Goldberg, Julie; Nguyen, Thuy-Tien D; Sasson, Noa; Lely, Justine; Smith, Bryan; King, Kelly A; Chisholm, Jennifer; Christensen, Julie; Magone, M Teresa; Cousineau-Krieger, Chantal; Hafiz, Rakibul; Nayak, Amritha; Irfanoglu, Okan; Attaripour, Sanaz; Lai, Chen; Smith, Wendy B.
Afiliação
  • Chan L; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Hallett M; The Military Traumatic Brain Injury Initiative, Bethesda, Maryland.
  • Zalewski CK; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
  • Brewer CC; National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
  • Zampieri C; National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
  • Hoa M; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Lippa SM; National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
  • Fitzgibbon E; National Intrepid Center of Excellence Walter Reed National Military Medical Center, Bethesda, Maryland.
  • French LM; Uniformed Services University of the Health Sciences, Bethesda, Maryland.
  • Moses AD; National Eye Institute, National Institutes of Health, Bethesda, Maryland.
  • van der Merwe AJ; National Intrepid Center of Excellence Walter Reed National Military Medical Center, Bethesda, Maryland.
  • Pierpaoli C; Uniformed Services University of the Health Sciences, Bethesda, Maryland.
  • Turtzo LC; The Military Traumatic Brain Injury Initiative, Bethesda, Maryland.
  • Yonter S; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, Maryland.
  • Shahim P; The Military Traumatic Brain Injury Initiative, Bethesda, Maryland.
  • Moore B; Laboratory on Quantitative Medical Imaging, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland.
  • Stamps L; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
  • Flynn S; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Fontana J; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Tata S; The Military Traumatic Brain Injury Initiative, Bethesda, Maryland.
  • Fernandez MA; The Military Traumatic Brain Injury Initiative, Bethesda, Maryland.
  • Joseph AL; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, Maryland.
  • Matsubara J; The Military Traumatic Brain Injury Initiative, Bethesda, Maryland.
  • Goldberg J; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, Maryland.
  • Nguyen TD; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Sasson N; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Lely J; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Smith B; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • King KA; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Chisholm J; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Christensen J; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Magone MT; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Cousineau-Krieger C; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Hafiz R; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Nayak A; Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
  • Irfanoglu O; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
  • Attaripour S; National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
  • Lai C; National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
  • Smith WB; National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
JAMA ; 331(13): 1109-1121, 2024 04 02.
Article em En | MEDLINE | ID: mdl-38497797
ABSTRACT
Importance Since 2015, US government and related personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure. The US government has labeled these anomalous health incidents (AHIs).

Objective:

To assess whether participants with AHIs differ significantly from US government control participants with respect to clinical, research, and biomarker assessments. Design, Setting, and

Participants:

Exploratory study conducted between June 2018 and July 2022 at the National Institutes of Health Clinical Center, involving 86 US government staff and family members with AHIs from Cuba, Austria, China, and other locations as well as 30 US government control participants. Exposures AHIs. Main Outcomes and

Measures:

Participants were assessed with extensive clinical, auditory, vestibular, balance, visual, neuropsychological, and blood biomarkers (glial fibrillary acidic protein and neurofilament light) testing. The patients were analyzed based on the risk characteristics of the AHI identifying concerning cases as well as geographic location.

Results:

Eighty-six participants with AHIs (42 women and 44 men; mean [SD] age, 42.1 [9.1] years) and 30 vocationally matched government control participants (11 women and 19 men; mean [SD] age, 43.8 [10.1] years) were included in the analyses. Participants with AHIs were evaluated a median of 76 days (IQR, 30-537) from the most recent incident. In general, there were no significant differences between participants with AHIs and control participants in most tests of auditory, vestibular, cognitive, or visual function as well as levels of the blood biomarkers. Participants with AHIs had significantly increased fatigue, depression, posttraumatic stress, imbalance, and neurobehavioral symptoms compared with the control participants. There were no differences in these findings based on the risk characteristics of the incident or geographic location of the AHIs. Twenty-four patients (28%) with AHI presented with functional neurological disorders. Conclusions and Relevance In this exploratory study, there were no significant differences between individuals reporting AHIs and matched control participants with respect to most clinical, research, and biomarker measures, except for objective and self-reported measures of imbalance and symptoms of fatigue, posttraumatic stress, and depression. This study did not replicate the findings of previous studies, although differences in the populations included and the timing of assessments limit direct comparisons.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Família / Governo Limite: Adult / Female / Humans / Male Idioma: En Revista: JAMA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Família / Governo Limite: Adult / Female / Humans / Male Idioma: En Revista: JAMA Ano de publicação: 2024 Tipo de documento: Article