Curcumin and omega-3 polyunsaturated fatty acids as bioactive food components with synergistic effects on Alzheimer's disease.
Psychogeriatrics
; 24(3): 701-718, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38528391
ABSTRACT
Curcumin and omega-3 polyunsaturated fatty acids (ω-3 PUFA) are multifunctional compounds which play an important role in Alzheimer's disease (AD) and little has been addressed about the role of these two compounds together in the progression of the disease. There is evidence of the beneficial effect of combined administration of ω-3 PUFA and other dietary supplements such as vitamins and polyphenols in the prevention of AD, although much remains to be understood about their possible complementary or synergistic activity. Therefore, the objective of this work is to review the research focused on studying the effect and mechanisms of action of curcumin, ω-3 PUFA, and the combination of these nutraceutical compounds, particularly on AD, and to integrate the possible ways in which these compounds can potentiate their effect. The most important pathophysiologies that manifest in AD will be addressed, in order to have a better understanding of the mechanisms of action through which these bioactive compounds exert a neuroprotective effect.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
/
Fármacos Neuroprotetores
/
Suplementos Nutricionais
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Curcumina
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Doença de Alzheimer
Limite:
Humans
Idioma:
En
Revista:
Psychogeriatrics
Assunto da revista:
GERIATRIA
/
PSICOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
México