The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity.

Helvacioglu, Sinem; Charehsaz, Mohammad; Bankoglu, Ezgi Eyluel; Stopper, Helga; Aydin, Ahmet

Helvacioglu, Sinem; Charehsaz, Mohammad; Bankoglu, Ezgi Eyluel; Stopper, Helga; Aydin, Ahmet.

Afiliação

Helvacioglu S; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istinye University, Istanbul, Turkey.
Charehsaz M; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey.
Bankoglu EE; Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany.
Stopper H; Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany.
Aydin A; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey.

Drug Chem Toxicol ; : 1-13, 2024 Mar 26.

Article em En | MEDLINE | ID: mdl-38529831

Rosmarinic acid (RA) showed protective effect against doxorubicin-induced genotoxicity.Epigallocatechin gallate (EGCG) demonstrated pro-oxidant properties at high concentrations.EGCG and RA selectively targeted MDA-MB-231 cells.Synergistic effect was observed when EGCG or RA was administered together with Dox on breast cancer cells.

Palavras-chave

Ames test; Doxorubicin; comet assay; epigallocatechin gallate; micronucleus; rosmarinic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Drug Chem Toxicol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Turquia

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