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Associating white matter microstructural integrity and improvements in reactive stepping in people with Parkinson's Disease.
Monaghan, Andrew S; Ofori, Edward; Fling, Brett W; Peterson, Daniel S.
Afiliação
  • Monaghan AS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
  • Ofori E; College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
  • Fling BW; Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
  • Peterson DS; Molecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, USA.
Brain Imaging Behav ; 2024 Mar 26.
Article em En | MEDLINE | ID: mdl-38530517
ABSTRACT
Reactive steps are rapid responses after balance challenges. People with Parkinson's Disease (PwPD) demonstrate impaired reactive stepping, increasing fall-risk. Although PwPD can improve steps through practice, the neural mechanisms contributing to improved reactive stepping are poorly understood. This study investigated white-matter correlates of responsiveness to reactive step training in PwPD. In an eighteen-week multiple-baseline study, participants (n = 22) underwent baseline assessments (B1 and B2 two-weeks apart), a two-week training protocol, and post-training assessments immediately (P1) and two-months (P2) post-training. Assessments involved three backward reactive step trials, measuring anterior-posterior margin of stability (AP MOS), step length, and step latency. Tract-Based Spatial Statistics correlated white-matter integrity (fractional anisotropy (FA) and radial diffusivity (RD)) with retained (P2-B2) and immediate improvements (P1-B2) in stepping. Significant and sustained improvements in step length and AP MOS were observed. Greater retention of step length improvement correlated with increased FA in the left anterior thalamic radiation (ATR), left posterior thalamic radiation (PTR), left superior longitudinal fasciculus (SLF), and right inferior longitudinal fasciculus (ILF). Step latency retention was associated with lower RD in the left posterior corona radiata and left PTR. Immediate improvements in AP MOS correlated with increased FA of the right ILF, right SLF, and right corticospinal tract. Immediate step length improvements were associated with increased FA in right and left ATR and right SLF. These findings highlight the importance of white-matter microstructural integrity in motor learning and retention processes in PD and could aid in identifying individuals with PD who would benefit most from balance rehabilitation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Brain Imaging Behav Assunto da revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Brain Imaging Behav Assunto da revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos