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Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials.
Schmitz, Moniek G J; Aarts, Jasper G M; Burroughs, Laurence; Sudarsanam, Phanikrishna; Kuijpers, Tim J M; Riool, Martijn; de Boer, Leonie; Xue, Xuan; Bosnacki, Dragan; Zaat, Sebastian A J; de Boer, Jan; Alexander, Morgan R; Dankers, Patricia Y W.
Afiliação
  • Schmitz MGJ; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
  • Aarts JGM; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
  • Burroughs L; School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Sudarsanam P; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
  • Kuijpers TJM; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
  • Riool M; Department of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • de Boer L; Department of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • Xue X; School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Bosnacki D; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
  • Zaat SAJ; Department of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
  • de Boer J; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
  • Alexander MR; School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Dankers PYW; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Macromol Rapid Commun ; : e2300638, 2024 Mar 26.
Article em En | MEDLINE | ID: mdl-38530968
ABSTRACT
A polymer microarray based on the supramolecular ureido-pyrimidinone (UPy) moiety is fabricated to screen antimicrobial materials for their ability to support cell adhesion. UPy-functionalized additives, either cell-adhesive, antimicrobial or control peptides, are used, and investigated in different combinations at different concentrations, resulting in a library of 194 spots. These are characterized on composition and morphology to evaluate the microarray fabrication. Normal human dermal fibroblasts are cultured on the microarrays and cell adhesion to the spots is systematically analyzed. Results demonstrate enhanced cell adhesion on spots with combinations including the antimicrobial peptides. This study clearly proves the power of the high throughput approach in combination with supramolecular molecules, to screen additive libraries for desired biological response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Macromol Rapid Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Macromol Rapid Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda