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Exploring Borate-Modified Calcium Phosphate Ceramics: Antimicrobial Potential and Cytocompatibility Assessment.
Fadeeva, Inna V; Barbaro, Katia; Altigeri, Annalisa; Forysenkova, Anna A; Gafurov, Marat R; Mamin, Georgy V; Knot'ko, Alexander V; Yankova, Viktoriya G; Zhukova, Anna A; Russo, Fabrizio; Rau, Julietta V.
Afiliação
  • Fadeeva IV; A.A. Baikov Institute of Metallurgy and Material Science, Russian Academy of Sciences, Leninsky Prospect 49, 119334 Moscow, Russia.
  • Barbaro K; Istituto Zooprofilattico Sperimentale Lazio e Toscana "M. Aleandri", Via Appia Nuova 1411, 00178 Rome, Italy.
  • Altigeri A; Istituto Zooprofilattico Sperimentale Lazio e Toscana "M. Aleandri", Via Appia Nuova 1411, 00178 Rome, Italy.
  • Forysenkova AA; A.A. Baikov Institute of Metallurgy and Material Science, Russian Academy of Sciences, Leninsky Prospect 49, 119334 Moscow, Russia.
  • Gafurov MR; Institute of Physics, Kazan Federal University, Kremlyovskaya St. 18, 420008 Kazan, Russia.
  • Mamin GV; Institute of Physics, Kazan Federal University, Kremlyovskaya St. 18, 420008 Kazan, Russia.
  • Knot'ko AV; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
  • Yankova VG; Department of Analytical, Physical and Colloid Chemistry, I.M. Sechenov First Moscow State Medical University, Trubetskaya 8, Build. 2, 119048 Moscow, Russia.
  • Zhukova AA; Department of Analytical, Physical and Colloid Chemistry, I.M. Sechenov First Moscow State Medical University, Trubetskaya 8, Build. 2, 119048 Moscow, Russia.
  • Russo F; Laboratory of Regenerative Orthopaedics, Research Unit of Orthopaedic, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
  • Rau JV; Operative Research Unit of Orthopaedics, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, Italy.
Nanomaterials (Basel) ; 14(6)2024 Mar 09.
Article em En | MEDLINE | ID: mdl-38535643
ABSTRACT
Addressing periprosthetic infections, which present significant healing challenges that often require revision surgeries, necessitates the development of novel antibacterial materials and implants. Current research focuses on creating materials that hinder bacterial adhesion, colonization, and proliferation in surrounding tissues. Boron (B)-containing compounds are known for their antibacterial properties and potential in bone metabolism for regenerative medicine. In this study, we synthesized B-containing tricalcium phosphate (0.3B-TCP) with 1.1 wt.% B content via precipitation from aqueous solutions and sintering at 1100 °C. X-ray diffraction confirmed the ceramic's primary crystalline phase as ß-TCP, with B evenly distributed according to energy-dispersive spectroscopy data. Electron paramagnetic resonance (EPR) data verified stable paramagnetic borate anions, indicating successful BO33- substitution for phosphate groups. The microstructural properties of 0.3B-TCP ceramic were assessed before and after soaking in a saline solution. Its bending strength was approximately 30 MPa, and its porosity was about 33%. 0.3B-TCP ceramic demonstrated significant antimicrobial efficacy against various bacterial strains and a fungus. Cytotoxicity evaluation using equine adipose tissue-derived mesenchymal stem cells and osteogenic differentiation assessment were conducted. The combination of antibacterial efficacy and good cytocompatibility suggests 0.3B-TCP ceramic as a promising bone substitute material.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Federação Russa

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Federação Russa