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Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis.
Chang Estrada, Jorge Eduardo; Guerrero, Taissa Nunes; Reyes-Enríquez, Daniel Fernando; Nardy, Erica Santos; Guimarães Ferreira, Roseane; Ruiz Calderón, Cristian José; Wellmann, Irmgardt A; Monteiro Espíndola, Kaio Murilo; do Prado, Alejandro Ferraz; Soares, Andreimar Martins; Fontes, Marcos Roberto de Mattos; Chagas Monteiro, Marta; Zingali, Russolina Benedeta.
Afiliação
  • Chang Estrada JE; Instituto de Bioquímica Médica Leopoldo de Meis CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
  • Guerrero TN; Instituto de Bioquímica Médica Leopoldo de Meis CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
  • Reyes-Enríquez DF; Instituto de Bioquímica Médica Leopoldo de Meis CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
  • Nardy ES; Instituto de Bioquímica Médica Leopoldo de Meis CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
  • Guimarães Ferreira R; Postgraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Ruiz Calderón CJ; Department of Biochemistry and Microbiology, Universidad del Valle de Guatemala, Guatemala City 01015, Guatemala.
  • Wellmann IA; Postgraduate Program in Tropical Medicine, State University of Amazonas, Manaus 69005-010, AM, Brazil.
  • Monteiro Espíndola KM; Faculty of Medical Sciences, Universidad de San Carlos de Guatemala, Guatemala City 01015, Guatemala.
  • do Prado AF; Postgraduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Soares AM; Laboratory of Pharmacology and Toxicology of Cardiovascular System, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Fontes MRM; Laboratory of Biotechnology and Education Applied to One Health (LABIOPROT), Oswaldo Cruz Foundation, FIOCRUZ, RONDÔNIA, Federal University of Rondônia, UNIR, Porto Velho 76812-245, RO, Brazil.
  • Chagas Monteiro M; Sao Lucas University Center, SÃO LUCAS PVH, Porto Velho 76804-414, RO, Brazil.
  • Zingali RB; Western Amazon Research and Knowledge Network of Excellence (RED-CONEXAO), Basic and Applied Toxinology Research Network (RED-TOX), the National Institute of Science and Technology of Epidemiology of the Western Amazon (INCT EpiAmO), Porto Velho 76812-245, Ro, Brazil.
Toxins (Basel) ; 16(3)2024 Mar 08.
Article em En | MEDLINE | ID: mdl-38535808
ABSTRACT
Central America is home to one of the most abundant herpetofauna in the Americas, occupying only 7% of the continent's total area. Vipers and lizards are among the most relevant venomous animals in medical practice due to the consequences of envenomation from the bite of these animals. A great diversity of biomolecules with immense therapeutic and biotechnological value is contained in their venom. This paper describes the prominent leading representatives of the family Viperidae, emphasizing their morphology, distribution, habitat, feeding, and venom composition, as well as the biotechnological application of some isolated components from the venom of the animals from these families, focusing on molecules with potential anti-thrombotic action. We present the leading protein families that interfere with blood clotting, platelet activity, or the endothelium pro-thrombotic profile. In conclusion, Central America is an endemic region of venomous animals that can provide many molecules for biotechnological applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose Limite: Animals País/Região como assunto: America central Idioma: En Revista: Toxins (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose Limite: Animals País/Região como assunto: America central Idioma: En Revista: Toxins (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil