Limitations in membrane protein structure determination by lipid nanodiscs.
Trends Biochem Sci
; 49(6): 475-476, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38538407
ABSTRACT
Lipid nanodiscs are popular mimetics of biological membranes for determining membrane protein structures. However, a recent study revealed that the choice of nanodisc scaffold directly influenced the structure of an ion channel. This finding prompts us to be cautious and calls for improved membrane mimetics for structure determination.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nanoestruturas
/
Proteínas de Membrana
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2024
Tipo de documento:
Article