The Hallmarks of Precancer.

Stangis, Mary M; Chen, Zhengyi; Min, Jimin; Glass, Sarah E; Jackson, Jordan O; Radyk, Megan D; Hoi, Xen Ping; Brennen, W Nathaniel; Yu, Ming; Dinh, Huy Q; Coffey, Robert J; Shrubsole, Martha J; Chan, Keith S; Grady, William M; Yegnasubramanian, Srinivasan; Lyssiotis, Costas A; Maitra, Anirban; Halberg, Richard B; Dey, Neelendu; Lau, Ken S

Stangis, Mary M; Chen, Zhengyi; Min, Jimin; Glass, Sarah E; Jackson, Jordan O; Radyk, Megan D; Hoi, Xen Ping; Brennen, W Nathaniel; Yu, Ming; Dinh, Huy Q; Coffey, Robert J; Shrubsole, Martha J; Chan, Keith S; Grady, William M; Yegnasubramanian, Srinivasan; Lyssiotis, Costas A; Maitra, Anirban; Halberg, Richard B; Dey, Neelendu; Lau, Ken S.

Afiliação

Stangis MM; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Chen Z; Gastroenterology Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Min J; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Glass SE; Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jackson JO; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Radyk MD; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Hoi XP; Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas.
Brennen WN; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Yu M; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Dinh HQ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.
Coffey RJ; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Shrubsole MJ; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan.
Chan KS; Department of Urology, Houston Methodist Research Institute, Houston, Texas.
Grady WM; Neal Cancer Center, Houston Methodist Research Institute, Houston, Texas.
Yegnasubramanian S; Genitourinary Cancer Disease Division, Department of Oncology, Johns Hopkins Medicine, Baltimore, Maryland.
Lyssiotis CA; Department of Pharmacology and Molecular Sciences, Johns Hopkins Medicine, Baltimore, Maryland.
Maitra A; Department of Urology, Johns Hopkins Medicine, Baltimore, Maryland.
Halberg RB; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Dey N; Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington.
Lau KS; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.

Cancer Discov ; 14(4): 683-689, 2024 Apr 04.

Article em En | MEDLINE | ID: mdl-38571435

ABSTRACT

ABSTRACT

Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

Assuntos

Lesões Pré-Cancerosas; Humanos; Lesões Pré-Cancerosas/genética; Lesões Pré-Cancerosas/patologia; Fatores de Risco

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas Limite: Humans Idioma: En Revista: Cancer Discov Ano de publicação: 2024 Tipo de documento: Article

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