Ignorance is bliss: Inhibition of proteomic stress sensing improves direct neuronal conversion.

Traxler, Larissa; Borgogno, Oliver; Mertens, Jerome

Traxler, Larissa; Borgogno, Oliver; Mertens, Jerome.

Afiliação

Traxler L; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Borgogno O; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Mertens J; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. Electronic address: jmertens@health.ucsd.edu.

Neuron ; 112(7): 1035-1037, 2024 Apr 03.

Article em En | MEDLINE | ID: mdl-38574725

ABSTRACT

ABSTRACT

Direct conversion of non-neuronal cells to neurons offers opportunities for disease modeling and therapy. In this issue of Neuron, Sonsalla et al.1 reveal the unfolded protein response (UPR) pathway as a "proteomic roadblock" to direct neuronal conversion; overcoming this roadblock enhances reprogramming.

Assuntos

Neurônios; Proteômica; Neurônios/metabolismo; Resposta a Proteínas não Dobradas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteômica / Neurônios Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

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