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The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses.
Quinteros, Susel Loli; Snyder, Nathaniel W; Chatoff, Adam; Ryan, Fiona; O'Brien, Bronwyn; Donnelly, Sheila.
Afiliação
  • Quinteros SL; University of Technology Sydney, Ultimo, Sydney, NSW, Australia.
  • Snyder NW; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
  • Chatoff A; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
  • Ryan F; University of Technology Sydney, Ultimo, Sydney, NSW, Australia.
  • O'Brien B; University of Technology Sydney, Ultimo, Sydney, NSW, Australia.
  • Donnelly S; University of Technology Sydney, Ultimo, Sydney, NSW, Australia.
Eur J Immunol ; 54(6): e2350643, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38581085
ABSTRACT
We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Helminto / Macrófagos Limite: Animals Idioma: En Revista: Eur J Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Helminto / Macrófagos Limite: Animals Idioma: En Revista: Eur J Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália