Association between obesity and cancer risk in adults with HIV in Korea.
AIDS
; 38(9): 1386-1394, 2024 07 15.
Article
em En
| MEDLINE
| ID: mdl-38597513
ABSTRACT
INTRODUCTION:
This study aimed to investigate the association between obesity and cancer risk as well as site-specific cancer risks in adults with HIV using a nationwide health screening database in Korea.METHODS:
Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1ââ4 ratio) were included in this nested case-control study. The association between obesity (BMI ≥25âkg/m 2 ) and cancer risks was estimated and presented as odds ratios (ORs) and 95% confidence intervals (95% CIs).RESULTS:
Of the 456 cancer incident cases, there were 146 AIDS-defining cancer cases and 310 non-AIDS-defining cancer cases. Compared with nonobese adults with HIV, obese adults with HIV were at higher risk of non-AIDS-defining cancer (ORâ=â1.478, 95% CIâ=â1.118-1.955). Otherwise, the overall risk of AIDS-defining cancer (ORâ=â0.816, 95% CIâ=â0.520-1.279) and each type of AIDS-defining cancer (Kaposi sarcoma and non-Hodgkin's lymphoma) were not high in obese adults with HIV. Of the specific types of non-AIDS-defining cancers, obesity was associated with an increased risk of colorectal cancer (ORâ=â3.090, 95% CIâ=â1.110-8.604) and liver, bile duct, and pancreatic cancers (ORâ=â2.532, 95% CIâ=â1.141-5.617).CONCLUSION:
Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Neoplasias
/
Obesidade
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2024
Tipo de documento:
Article