Mechanisms of the role of proto-oncogene activation in promoting malignant transformation of mature B cells. / åç¤åºå æ¿æ´»è¯±å¯¼æçBç»èæ¶åçä½ç¨æºå¶.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 49(1): 113-121, 2024 Jan 28.
Article
em En, Zh
| MEDLINE
| ID: mdl-38615172
ABSTRACT
Malignant tumors continue to pose a significant threat to human life and safety and their development is primarily due to the activation of proto-oncogenes and the inactivation of suppressor genes. Among these, the activation of proto-oncogenes possesses greater potential to drive the malignant transformation of cells. Targeting oncogenes involved in the malignant transformation of tumor cells has provided a novel approach for the development of current antitumor drugs. Several preclinical and clinical studies have revealed that the development pathway of B cells, and the malignant transformation of mature B cells into tumors have been regulated by oncogenes and their metabolites. Therefore, summarizing the key oncogenes involved in the process of malignant transformation of mature B cells and elucidating the mechanisms of action in tumor development hold significant importance for the clinical treatment of malignant tumors.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Neoplasias
Limite:
Humans
Idioma:
En
/
Zh
Revista:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Assunto da revista:
MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article