Trimethylsilanol Cleaves Stable Azaylides As Revealed by Unfolding of Robust "Staudinger" Single-Chain Nanoparticles.
ACS Polym Au
; 4(2): 140-148, 2024 Apr 10.
Article
em En
| MEDLINE
| ID: mdl-38618005
ABSTRACT
Herein, we disclose a unique and selective reagent for the cleavage of stable azaylides prepared by the nonhydrolysis Staudinger reaction, enabling the on-demand unfolding of robust single-chain nanoparticles (SCNPs). SCNPs with promising use in catalysis, nanomedicine, and sensing are obtained through intrachain folding of discrete synthetic polymer chains. The unfolding of SCNPs involving reversible interactions triggered by a variety of external stimuli (e.g., pH, temperature, light, and redox potential) or substances (e.g., competitive reagents, solvents, and anions) is well known. Conversely, methods for the unfolding (i.e., intrachain disassembly) of SCNPs with stronger covalent interactions are scarce. We show that trimethylsilanol (Me3SiOH) triggers the efficient unfolding of robust "Staudinger" SCNPs with stable azaylide (-N=P-) moieties as intrachain cross-linking units showing exceptional stability toward water, air, and CS2, a standard reagent for azaylides. As a consequence, Me3SiOH arises as a rare, exceptional, and valuable reagent for the cleavage of stable azaylides prepared by the nonhydrolysis Staudinger reaction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
ACS Polym Au
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha