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Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia.
Castillo, Ulises G; Uekusa, Yoshinori; Nishimura, Takehiro; Kiuchi, Fumiyuki; Martínez, Morena L; Menjívar, Jenny; Nakajima-Shimada, Junko; Núñez, Marvin J; Kikuchi, Haruhisa.
Afiliação
  • Castillo UG; Laboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Avenida de Mártires y Héroes del 30 de Julio, San Salvador 1101, El Salvador.
  • Uekusa Y; Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
  • Nishimura T; Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
  • Kiuchi F; Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
  • Martínez ML; Laboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Avenida de Mártires y Héroes del 30 de Julio, San Salvador 1101, El Salvador.
  • Menjívar J; Museo de Historia Natural de El Salvador, Ministerio de Cultura, San Salvador 1101, El Salvador.
  • Nakajima-Shimada J; Graduate School of Health Science, Gunma University, 3-39-22 Showamachi, Maebashi, Gunma 371-8514, Japan.
  • Núñez MJ; Laboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Avenida de Mártires y Héroes del 30 de Julio, San Salvador 1101, El Salvador.
  • Kikuchi H; Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
J Nat Prod ; 87(4): 1067-1074, 2024 04 26.
Article em En | MEDLINE | ID: mdl-38631020
ABSTRACT
A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Lignanas / Peperomia País/Região como assunto: America central / El salvador Idioma: En Revista: J Nat Prod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: El Salvador
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Lignanas / Peperomia País/Região como assunto: America central / El salvador Idioma: En Revista: J Nat Prod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: El Salvador