Engineered Living Structures with Shape-Morphing Capability Enabled by 4D Printing with Functional Bacteria.
ACS Appl Bio Mater
; 7(5): 3247-3257, 2024 05 20.
Article
em En
| MEDLINE
| ID: mdl-38648508
ABSTRACT
Engineered living structures with the incorporation of functional bacteria have been explored extensively in recent years and have shown promising potential applications in biosensing, environmental remediation, and biomedicine. However, it is still rare and challenging to achieve multifunctional capabilities such as material production, shape transformation, and sensing in a single-engineered living structure. In this study, we demonstrate bifunctional living structures by synergistically integrating cellulose-generating bacteria with pH-responsive hydrogels, and the entire structures can be precisely fabricated by three-dimensional (3D) printing. Such 3D-printed bifunctional living structures produce cellulose nanofibers in ambient conditions and have reversible and controlled shape-morphing properties (usually referred to as four-dimensional printing). Those functionalities make them biomimetic versions of silkworms in the sense that both can generate nanofibers and have body motion. We systematically investigate the processing-structure-property relationship of the bifunctional living structures. The on-demand separation of 3D cellulose structures from the hydrogel template and the living nature of the bacteria after processing and shape transformation are also demonstrated.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
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Teste de Materiais
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Celulose
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Hidrogéis
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Impressão Tridimensional
Limite:
Animals
Idioma:
En
Revista:
ACS Appl Bio Mater
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos