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Interactions of catecholamines and GABA+ in cognitive control: Insights from EEG and 1H-MRS.
Koyun, Anna Helin; Talebi, Nasibeh; Werner, Annett; Wendiggensen, Paul; Kuntke, Paul; Roessner, Veit; Beste, Christian; Stock, Ann-Kathrin.
Afiliação
  • Koyun AH; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, Dresden D-01307, Germany.
  • Talebi N; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, Dresden D-01307, Germany.
  • Werner A; Institute of Diagnostic and Interventional Neuroradiology, TU Dresden, Germany.
  • Wendiggensen P; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, Dresden D-01307, Germany.
  • Kuntke P; Institute of Diagnostic and Interventional Neuroradiology, TU Dresden, Germany.
  • Roessner V; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, Dresden D-01307, Germany.
  • Beste C; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, Dresden D-01307, Germany.
  • Stock AK; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Schubertstrasse 42, Dresden D-01307, Germany. Electronic address: ann-kathrin.stock@ukdd.de.
Neuroimage ; 293: 120619, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38679186
ABSTRACT
Catecholamines and amino acid transmitter systems are known to interact, the exact links and their impact on cognitive control functions have however remained unclear. Using a multi-modal imaging approach combining EEG and proton-magnetic resonance spectroscopy (1H-MRS), we investigated the effect of different degrees of pharmacological catecholaminergic enhancement onto theta band activity (TBA) as a measure of interference control during response inhibition and execution. It was central to our study to evaluate the predictive impact of in-vivo baseline GABA+ concentrations in the striatum, the anterior cingulate cortex (ACC) and the supplemental motor area (SMA) of healthy adults under varying degrees of methylphenidate (MPH) stimulation. We provide evidence for a predictive interrelation of baseline GABA+ concentrations in cognitive control relevant brain areas onto task-induced TBA during response control stimulated with MPH. Baseline GABA+ concentrations in the ACC, the striatum, and the SMA had a differential impact on predicting interference control-related TBA in response execution trials. GABA+ concentrations in the ACC appeared to be specifically important for TBA modulations when the cognitive effort needed for interference control was high - that is when no prior task experience exists, or in the absence of catecholaminergic enhancement with MPH. The study highlights the predictive role of baseline GABA+ concentrations in key brain areas influencing cognitive control and responsiveness to catecholaminergic enhancement, particularly in high-effort scenarios.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecolaminas / Cognição / Eletroencefalografia / Espectroscopia de Prótons por Ressonância Magnética / Ácido gama-Aminobutírico / Metilfenidato Limite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecolaminas / Cognição / Eletroencefalografia / Espectroscopia de Prótons por Ressonância Magnética / Ácido gama-Aminobutírico / Metilfenidato Limite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha