Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review.
Asian J Urol
; 11(2): 191-207, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38680577
ABSTRACT
Objective:
To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic diseases.Methods:
A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect model.Results:
Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI] -0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI 0.78-1.88) and between high and low PLR was 1.47 (95% CI 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI 1.44-2.13) and between high and low PLR was 1.05 (95% CI 0.87-1.24).Conclusion:
The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Asian J Urol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália