Epigenetic Control of Cancer Cell Dormancy and Awakening in Endocrine Therapy Resistance.
Cancer Discov
; 14(5): 704-706, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38690600
ABSTRACT
SUMMARY:
Rosano, Sofyali, Dhiman, and colleagues show that epigenetic-related changes occur in endocrine therapy (ET)-induced dormancy in estrogen receptor positive (ER+) breast cancer, as well as in its reawakening. Targeting these epigenetic changes blocks the entrance to dormancy and reduces the persister cancer cell population, enhancing the cytotoxic effects of ET in vitro. See related article by Rosano et al., p. 866 (9).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Resistencia a Medicamentos Antineoplásicos
/
Antineoplásicos Hormonais
/
Epigênese Genética
Limite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Discov
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha