Association of Plasma Amyloid-ß and Dementia Among Black and White Older Adults.
J Alzheimers Dis
; 99(2): 787-797, 2024.
Article
em En
| MEDLINE
| ID: mdl-38701147
ABSTRACT
Background:
Plasma amyloid-ß (Aß) has emerged as an important tool to detect risks of Alzheimer's disease and related dementias, although research in diverse populations is lacking.Objective:
We compared plasma Aß42/40 by race with dementia risk over 15 years among Black and White older adults.Methods:
In a prospective cohort of 997 dementia-free participants (mean age 74±2.9 years, 55% women, 54% Black), incident dementia was identified based on hospital records, medication, and neurocognitive test over 15 years. Plasma Aß42/40 was measured at Year 2 and categorized into low, medium, and high tertile. We used linear regression to estimate mean Aß42/40 by race and race-stratified Cox proportional hazards models to assess the association between Aß42/40 tertile and dementia risk.Results:
Black participants had a lower age-adjusted mean Aß 42/40 compared to White participants, primarily among APOE É4 non-carriers (Black 0.176, White 0.185, pâ=â0.035). Among Black participants, lower Aß 42/40 was associated with increased dementia risk 33% in low (hazard ratios [HR]â=â1.77, 95% confidence interval 1.09-2.88) and 27% in medium tertile (HRâ=â1.67, 1.01-2.78) compared with 18% in high Aß 42/40 tertile; Increased risks were attenuated among Whiteparticipants:
21% in low (HRâ=â1.43, 0.81-2.53) and 23% in medium tertile (HRâ=â1.27, 0.68-2.36) compared with 15% in high Aß 42/40 tertile. The interaction by race was not statistically significant.Conclusions:
Among community-dwelling, non-demented older adults, especially APOE É4 non-carriers, Black individuals had lower plasma Aß 42/40 and demonstrated a higher dementia risk with low Aß42/40 compared with White individuals.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Negro ou Afro-Americano
/
Peptídeos beta-Amiloides
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Demência
/
População Branca
Limite:
Aged
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Aged80
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Female
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Humans
/
Male
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos