Transforming growth factor beta-1 (TGF-ß1) expression in patients with adenomyosis.
Rev Bras Ginecol Obstet
; 462024.
Article
em En
| MEDLINE
| ID: mdl-38765506
ABSTRACT
Objective:
To compare Transforming growth factor beta-1 (TGF-ß1) expression in patients with and without adenomyosis.Methods:
A prospective design was performed including 49 patients submitted to hysterectomy. Immunohistochemistry was performed on anatomopathological samples staged in paraffin blocks from patients with and without adenomyosis. The sample contained 28 adenomyosis cases and 21 controls. Student's t-test and multivariate logistic regression tests were used for statistical analysis. Associations were considered significant at p < 0.05.Results:
We found no significant association between adenomyosis and smoking (p = 0.75), miscarriage (p = 0.29), number of previous pregnancies (p = 0.85), curettage (p = 0.81), pelvic pain (p = 0.72) and myoma (p = 0.15). However, we did find a relationship between adenomyosis and abnormal uterine bleeding (AUB) (p = 0.02) and previous cesarean section (p = 0.02). The mean TGF-ß1 intensity (mean ± SD) in the ectopic endometrium of women with adenomyosis showed no significant association (184.17 ± 9.4 vs.184.66 ± 16.08, p = 0.86) from the topic endometrium of women without adenomyosis.Conclusion:
TGF-ß1 expression was not increased in the ectopic endometrium of women with adenomyosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Transformador beta1
/
Adenomiose
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Rev Bras Ginecol Obstet
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil