High expression of serine protease inhibitor kazal type 1 predicts poor prognosis and promotes the progression and invasion of oral tongue squamous cell carcinoma.
Arch Oral Biol
; 164: 106003, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38781741
ABSTRACT
OBJECTIVE:
This study aimed to investigate the expression of serine protease inhibitor kazal type 1 (SPINK1) and its carcinogenic effect in oral tongue squamous cell carcinoma (OTSCC).DESIGN:
Initially, bioinformatics analysis was conducted using data from The Cancer Genome Atlas and Gene Expression Omnibus to compare SPINK1 mRNA expression between malignant and adjacent tissues. Subsequently, the impact of differential expression on survival and other clinical variables was examined. Additionally, histology microarray analysis was performed to assess SPINK1 protein expression in 35 cases of malignant and adjacent tissues. Finally, alterations in SPINK1 expression were evaluated to determine its biological phenotypes in OTSCC, including proliferation, apoptosis, invasion, and metastasis.RESULTS:
OTSCC tissues exhibit higher levels of SPINK1 compared to surrounding cancerous tissues. Notably, increased SPINK1 expression correlates with the pathological N stage and independently predicts overall survival among patients with OTSCC.CONCLUSION:
Suppression of SPINK1 inhibited OTSCC cell proliferation, invasion, and motility while promoting apoptosis. These findings suggest that SPINK1 may serve as a prognostic biomarker as well as a potential therapeutic target for managing OTSCC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Língua
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Carcinoma de Células Escamosas
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Biomarcadores Tumorais
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Inibidor da Tripsina Pancreática de Kazal
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Apoptose
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Progressão da Doença
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Proliferação de Células
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Invasividade Neoplásica
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arch Oral Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China