The autoimmune landscape of Porto-sinusoidal vascular disorder: What the rheumatologist needs to know.
Semin Arthritis Rheum
; 67: 152467, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38805899
ABSTRACT
Porto-sinusoidal vascular disorder (PSVD) encompasses a group of vascular disorders characterized by lesions of the portal venules and sinusoids with clinical manifestations ranging from non-specific abnormalities in serum liver enzymes to clinically overt portal hypertension and related complications. Several reports have documented cases of PSVD in patients with systemic autoimmune conditions, such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. It is of note that these diseases share specific pathophysiological features with PSVD, including endothelial dysfunction, vascular inflammation, and molecular signatures. This narrative review aims to summarize the current knowledge on the association between PSVD and systemic autoimmune diseases, emphasizing the importance of promptly recognizing this condition in the rheumatological practice, and highlighting the key aspects where further research is necessary from both pathogenic and clinical perspectives.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
Limite:
Humans
Idioma:
En
Revista:
Semin Arthritis Rheum
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália