COVID-19 vaccination safety and associated health care utilization among adults with inflammatory bowel disease - a population-based self-controlled case series analysis.
BMC Gastroenterol
; 24(1): 189, 2024 May 30.
Article
em En
| MEDLINE
| ID: mdl-38816836
ABSTRACT
BACKGROUND AND AIMS:
There is an incomplete understanding of the full safety profiles of repeated COVID-19 vaccinations in patients with inflammatory bowel disease (IBD). Among individuals with IBD, we assessed whether COVID-19 vaccines were associated with serious adverse events of special interest (AESI) and health care utilization [all-cause hospitalizations, Emergency Department (ED) visits, gastroenterology visits, IBD-related visits].METHODS:
Using comprehensive administrative health data from Ontario, Canada, adults with IBD who received at least one COVID-19 vaccine from December 2020-January 2022 were included. Self-controlled case series analyses were conducted to evaluate the relative incidence rates of AESI and health care utilization outcomes across post-vaccination risk and control periods.RESULTS:
Among 88,407 IBD patients, 99.7% received mRNA vaccines and 75.9% received ≥ 3 doses. Relative to control periods, we did not detect an increase in AESI. IBD patients had fewer all-cause hospitalizations during post-vaccination risk periods. Patients experienced more all-cause ED visits after dose 2 [Relative Incidence (RI)1.08(95%CI1.04-1.12)] but fewer visits after doses 3 [RI0.85 (95%CI0.81-0.90)] and 4 [RI0.73 (95%CI0.57-0.92)]. There was no increase in gastroenterologist visits or IBD-related health care utilization post-vaccination. There were fewer IBD-related hospitalizations after dose 1 [RI0.84 (95%CI0.72-0.98)] and 3 [RI0.63 (95%CI0.52-0.76)], fewer IBD-related ED visits after dose 3 [RI0.81 (95%CI0.71-0.91)] and 4 [RI0.55 (95%CI0.32-0.96)], and fewer outpatient visits after dose 2 [RI0.91 (95%CI0.90-0.93)] and 3 [RI0.87 (95%CI0.86-0.89)].CONCLUSION:
This population-based study did not detect increased AESI, all-cause or IBD-related health care utilization following COVID-19 vaccination, suggesting a lack of association between vaccination and increased disease activity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Aceitação pelo Paciente de Cuidados de Saúde
/
Vacinas contra COVID-19
/
COVID-19
/
Hospitalização
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
BMC Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá