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Physiological Microenvironment Dependent Self-Cross-Linking of Multifunctional Nanohybrid for Prolonged Antibacterial Therapy via Synergistic Chemodynamic-Photothermal-Biological Processes.
Liu, Yi; Chen, Wei; Mu, Wenyun; Zhou, Qian; Liu, Jie; Li, Baixue; Liu, Tao; Yu, Tingting; Hu, Nan; Chen, Xin.
Afiliação
  • Liu Y; College of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, People's Republic of China.
  • Chen W; Institute of Precision Medicine, Zigong Academy of Big Data and Artificial Intelligence in Medical Science, Zigong Fourth People's Hospital, Zigong 643000, People's Republic of China.
  • Mu W; Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institution of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiao Tong University, Xi'an 710049, People's Republic of China.
  • Zhou Q; Sichuan Clinical Research Center for Clinical Laboratory, Zigong Fourth People's Hospital, Zigong 643000, People's Republic of China.
  • Liu J; Institute of Precision Medicine, Zigong Academy of Big Data and Artificial Intelligence in Medical Science, Zigong Fourth People's Hospital, Zigong 643000, People's Republic of China.
  • Li B; Department of Urology, Zigong Fourth People's Hospital, Zigong 643000, People's Republic of China.
  • Liu T; Sichuan Clinical Research Center for Clinical Laboratory, Zigong Fourth People's Hospital, Zigong 643000, People's Republic of China.
  • Yu T; Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institution of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiao Tong University, Xi'an 710049, People's Republic of China.
  • Hu N; College of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, People's Republic of China.
  • Chen X; Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institution of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiao Tong University, Xi'an 710049, People's Republic of China.
Nano Lett ; 24(23): 6906-6915, 2024 Jun 12.
Article em En | MEDLINE | ID: mdl-38829311
ABSTRACT
Herein, a multifunctional nanohybrid (PL@HPFTM nanoparticles) was fabricated to perform the integration of chemodynamic therapy, photothermal therapy, and biological therapy over the long term at a designed location for continuous antibacterial applications. The PL@HPFTM nanoparticles consisted of a polydopamine/hemoglobin/Fe2+ nanocomplex with comodification of tetrazole/alkene groups on the surface as well as coloading of antimicrobial peptides and luminol in the core. During therapy, the PL@HPFTM nanoparticles would selectively cross-link to surrounding bacteria via tetrazole/alkene cycloaddition under chemiluminescence produced by the reaction between luminol and overexpressed H2O2 at the infected area. The resulting PL@HPFTM network not only significantly damaged bacteria by Fe2+-catalyzed ROS production, effective photothermal conversion, and sustained release of antimicrobial peptides but dramatically enhanced the retention time of these therapeutic agents for prolonged antibacterial therapy. Both in vitro and in vivo results have shown that our PL@HPFTM nanoparticles have much higher bactericidal efficiency and remarkably longer periods of validity than free antibacterial nanoparticles.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Nano Lett Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Nano Lett Ano de publicação: 2024 Tipo de documento: Article