Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform.

Dorighi, Kristel M; Zhu, Anqi; Fortin, Jean-Philippe; Hung-Hao Lo, Jerry; Sudhamsu, Jawahar; Wendorff, Timothy J; Durinck, Steffen; Callow, Marinella; Foster, Scott A; Haley, Benjamin

Dorighi, Kristel M; Zhu, Anqi; Fortin, Jean-Philippe; Hung-Hao Lo, Jerry; Sudhamsu, Jawahar; Wendorff, Timothy J; Durinck, Steffen; Callow, Marinella; Foster, Scott A; Haley, Benjamin.

Afiliação

Dorighi KM; Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address: dorighik@gene.com.
Zhu A; Department of OMNI Bioinformatics, Genentech, Inc., South San Francisco, CA 94080, USA.
Fortin JP; Department of Data Science and Statistical Computing, Genentech, Inc., South San Francisco, CA 94080, USA.
Hung-Hao Lo J; Department of Oncology Bioinformatics, Genentech, Inc., South San Francisco, CA 94080, USA.
Sudhamsu J; Department of Structural Biology, Genentech, Inc., South San Francisco, CA 94080, USA.
Wendorff TJ; Department of Structural Biology, Genentech, Inc., South San Francisco, CA 94080, USA.
Durinck S; Department of Oncology Bioinformatics, Genentech, Inc., South San Francisco, CA 94080, USA.
Callow M; Department of Discovery Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.
Foster SA; Department of Discovery Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.
Haley B; Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address: benjamin.haley@umontreal.ca.

Cell Rep ; 43(6): 114313, 2024 Jun 25.

Article em En | MEDLINE | ID: mdl-38838224

Assuntos

Resistencia a Medicamentos Antineoplásicos; Receptores ErbB; Humanos; Resistencia a Medicamentos Antineoplásicos/genética; Receptores ErbB/metabolismo; Receptores ErbB/genética; Receptores ErbB/antagonistas & inibidores; Linhagem Celular Tumoral; Edição de Genes/métodos; Proteínas Proto-Oncogênicas B-raf/genética; Proteínas Proto-Oncogênicas B-raf/metabolismo; Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores; Sistemas CRISPR-Cas/genética; Mutação/genética; Mutagênese

Palavras-chave

AID; BRAF; CP: Cancer; CRISPR-Cas9; EGFR; base editing; drug resistance; functional genomics; mutagenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Receptores ErbB Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2024 Tipo de documento: Article

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