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Variations in germ cell tumor histology by age and implications for cancer-specific survival among pediatric and adult males: A population-based study.
Mason, J Bradley; Srivastava, Arnav; Lanzotti, Nicholas J; Ellis, Jeffrey L; Carlo, Heather N Di; Gearhart, John P; Bowen, Diana K; Gupta, Mohit; Picken, Maria M; Gupta, Gopal N; Patel, Hiten D.
Afiliação
  • Mason JB; Department of Urology, MedStar Georgetown University Hospital, Washington, DC. Electronic address: jbradleymason@gmail.com.
  • Srivastava A; Section of Urologic Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; Department of Urology, University of Michigan, Ann Arbor, MI.
  • Lanzotti NJ; Department of Urology, Loyola University Medical Center, Maywood, IL.
  • Ellis JL; Department of Urology, Loyola University Medical Center, Maywood, IL.
  • Carlo HND; Department of Urology ,The James Buchanan Brady Urologic Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.
  • Gearhart JP; Department of Urology ,The James Buchanan Brady Urologic Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.
  • Bowen DK; Department of Urology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
  • Gupta M; Department of Urology, MedStar Georgetown University Hospital, Washington, DC.
  • Picken MM; Department of Pathology, Loyola University Medical Center, Maywood, IL.
  • Gupta GN; Department of Urology, Loyola University Medical Center, Maywood, IL.
  • Patel HD; Department of Urology, Loyola University Medical Center, Maywood, IL; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Urol Oncol ; 42(9): 292.e17-292.e26, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38839493
ABSTRACT

PURPOSE:

Few studies have quantified differences in histology and implications for survival between male children and adults with germ cell tumors (GCT). We evaluated these differences and associations with cancer-specific survival (CSS) using Surveillance, Epidemiology, and End Results (SEER) cancer registries.

METHODS:

SEER (1988-2016) was used to identify male patients 0 to 40 years of age diagnosed with seminoma and nonseminomatous GCT (NSGCT). Demographic and tumor characteristics were tabulated with histology distributions compared by age group (0-4, 12-18, 19-40 years old). CSS was evaluated in multivariable Cox proportional hazards regression models.

RESULTS:

Among 27,204 patients identified, 1,538 (5.7%) were pediatric (0-18 years). Seminoma (54.3%) predominated in adult patients (ages 19-40). Among 0 to 4 years-old, yolk sac tumor (71.2%) and teratoma (21.5%) were most common. Mixed GCT (52.7%) was most prevalent among 12 to 18 years-old with seminoma, embryonal, and teratoma occurring in 12 to 15% each. Relative to pediatric patients, adult patients had similar CSS for seminoma but worse CSS for NSGCT on Kaplan-Meier curves with 9 years mean follow-up. Choriocarcinoma and yolk sac tumors carried the worst prognosis relative to seminoma for both children (HR 5.7 and HR 11.1, respectively, both P < 0.01) and adults (HR 4.6 and HR 4.6, respectively, both P < 0.01) adjusted for stage.

CONCLUSION:

Histology of GCTs vary by age with yolk sac tumors and teratoma predominating for male patients 0 to 4 years, mixed GCT for 12 to 18 years, and seminoma for 19 to 40 years. Pediatric patients with NSGCT had higher CSS than their adult counterparts. Mixed GCT represented an increasing proportion of GCT over the study period. Age, stage, and histology impact CSS in both pediatric and adult populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Neoplasias Embrionárias de Células Germinativas Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Male / Newborn Idioma: En Revista: Urol Oncol Assunto da revista: NEOPLASIAS / UROLOGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Neoplasias Embrionárias de Células Germinativas Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Male / Newborn Idioma: En Revista: Urol Oncol Assunto da revista: NEOPLASIAS / UROLOGIA Ano de publicação: 2024 Tipo de documento: Article