Oral octreotide capsules for acromegaly treatment: application of clinical trial insights to real-world use.
Expert Rev Endocrinol Metab
; 19(4): 367-375, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38842362
ABSTRACT
INTRODUCTION:
Acromegaly is a rare endocrine disorder usually caused by a benign growth hormoneâsecreting pituitary adenoma. Surgical adenoma resection is typically the first line of treatment, and medical therapy is used for patients with persistent disease following surgery, for adenoma recurrence, or for patients ineligible for, or declining, surgery. Approved somatostatin receptor ligands (SRLs) have been limited to injectable options, until recently. Oral octreotide capsules (OOC) are the first approved oral SRL for patients with acromegaly. AREAS COVERED We review published reports and provide case study examples demonstrating practical considerations on the use of OOC. Using two hypothetical case scenarios, we discuss current treatment patterns, breakthrough symptoms and quality of life (QoL), efficacy of SRLs, OOC dose titration, evaluation of OOC treatment response, and incidence and management of adverse events. EXPERT OPINION OOC are an option for patients with acromegaly including those who experience breakthrough symptoms, who have preference for oral therapies, or other reasons for declining injectable SRLs. OOC have been associated with improved patient-reported QoL measures compared with those reported for lanreotide and octreotide. Continued real-world experience will determine whether OOC, alone or in combination with other therapies, provides further advantages over current injectable acromegaly treatments.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Acromegalia
/
Octreotida
/
Antineoplásicos Hormonais
Limite:
Humans
Idioma:
En
Revista:
Expert Rev Endocrinol Metab
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos