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Tongue coating-dependent superior temporal sulcus remodeling in amnestic mild cognitive impairment.
Lu, Juan-Juan; Ma, Jie; Wu, Jia-Jia; Zhen, Xiao-Min; Xiang, Yun-Ting; Lu, Hao-Yu; Zheng, Mou-Xiong; Hua, Xu-Yun; Xu, Jian-Guang.
Afiliação
  • Lu JJ; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Ma J; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Wu JJ; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Zhen XM; Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Xiang YT; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Lu HY; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Zheng MX; Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: zhengmouxiong@shutcm.edu.cn.
  • Hua XY; Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: huaxuyun@shutcm.edu.cn.
  • Xu JG; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Engineering Re
Brain Res Bull ; 214: 110995, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38844172
ABSTRACT
Tongue coating affects cognition, and cognitive decline at early stage also showed relations to functional and structural remodeling of superior temporal sulcus (STS) in amnestic mild cognitive impairment (aMCI). The potential correlation between disparate cognitive manifestations in aMCI patients with different tongue coatings, and corresponding mechanisms of STS remodeling remains uncharted. In this case-control study, aMCI patients were divided into thin coating (n = 18) and thick coating (n = 21) groups. All participants underwent neuropsychological evaluations and multimodal magnetic resonance imaging. Group comparisons were conducted in clinical assessments and neuroimaging measures of banks of the STS (bankssts). Generalized linear models were constructed to explore relationships between neuroimaging measures and cognition. aMCI patients in the thick coating group exhibited significantly poorer immediate and delayed recall and slower information processing speed (IPS) (P < 0.05), and decreased functional connectivity (FC) of bilateral bankssts with frontoparietal cortices (P < 0.05, AlphaSim corrected) compared to the thin coating group. It was found notable correlations between cognition encompassing recall and IPS, and FC of bilateral bankssts with frontoparietal cortices (P < 0.05, Bonferroni's correction), as well as interaction effects of group × regional homogeneity (ReHo) of right bankssts on the first immediate recall (P < 0.05, Bonferroni's correction). aMCI patients with thick coating exhibited poor cognitive performance, which might be attributed to decreased FC seeding from bankssts. Our findings strengthen the understanding of brain reorganization of STS via which tongue coating status impacts cognition in patients with aMCI.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Língua / Imageamento por Ressonância Magnética / Disfunção Cognitiva Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Res Bull Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Língua / Imageamento por Ressonância Magnética / Disfunção Cognitiva Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Res Bull Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China