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University of Washington Quality of Life subdomain outcomes after treatment of sinonasal malignancy: A prospective, multicenter study.
Maoz, Sabrina L; Golzar, Autreen; Choby, Garret; Hwang, Peter H; Wang, Eric W; Kuan, Edward C; Adappa, Nithin D; Geltzeiler, Mathew; Getz, Anne E; Humphreys, Ian M; Le, Christopher H; Pinheiro-Neto, Carlos D; Fischer, Jakob L; Chan, Erik P; Abuzeid, Waleed M; Chang, Eugene H; Jafari, Aria; Kingdom, Todd T; Kohanski, Michael A; Lee, Jivianne K; Lazor, Jillian W; Nabavizadeh, Ali; Nayak, Jayakar V; Palmer, James N; Patel, Zara M; Resnick, Adam C; Smith, Timothy L; Snyderman, Carl H; St John, Maie A; Storm, Phillip B; Suh, Jeffrey D; Wang, Marilene B; Sim, Myung S; Beswick, Daniel M.
Afiliação
  • Maoz SL; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Golzar A; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Choby G; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Hwang PH; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Wang EW; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Kuan EC; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA.
  • Adappa ND; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Geltzeiler M; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Getz AE; Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
  • Humphreys IM; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Le CH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Pinheiro-Neto CD; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Fischer JL; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Chan EP; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Abuzeid WM; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Chang EH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Jafari A; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Kingdom TT; Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
  • Kohanski MA; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Lee JK; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Lazor JW; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Nabavizadeh A; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Nayak JV; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Palmer JN; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Patel ZM; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Resnick AC; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Smith TL; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Snyderman CH; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • St John MA; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Storm PB; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Suh JD; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Wang MB; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Sim MS; Department of Medicine-Statistics Core, University of California Los Angeles, Los Angeles, California, USA.
  • Beswick DM; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
Int Forum Allergy Rhinol ; 14(10): 1568-1581, 2024 Oct.
Article em En | MEDLINE | ID: mdl-38884276
ABSTRACT

PURPOSE:

Sinonasal malignancies (SNMs) adversely impact patients' quality of life (QOL) and are frequently identified at an advanced stage. Because these tumors are rare, there are few studies that examine the specific QOL areas that are impacted. This knowledge would help improve the care of these patients.

METHODS:

In this prospective, multi-institutional study, 273 patients with SNMs who underwent definitive treatment with curative intent were evaluated. We used the University of Washington Quality of Life (UWQOL) instrument over 5 years from diagnosis to identify demographic, treatment, and disease-related factors that influence each of the 12 UWQOL subdomains from baseline to 5 -years post-treatment.

RESULTS:

Multivariate models found endoscopic resection predicted improved pain (vs. nonsurgical treatment CI 2.4, 19.4, p = 0.01) and appearance versus open (CI 27.0, 35.0, p < 0.001) or combined (CI 10.4, 17.1, p < 0.001). Pterygopalatine fossa involvement predicted worse swallow (CI -10.8, -2.4, p = 0.01) and pain (CI -17.0, -4.0, p < 0.001). Neck dissection predicted worse swallow (CI -14.8, -2.8, p < 0.001), taste (CI -31.7, -1.5, p = 0.02), and salivary symptoms (CI -28.4, -8.6, p < 0.001). Maxillary involvement predicted worse chewing (CI 9.8, 33.2; p < 0.001) and speech (CI -21.8, -5.4, p < 0.001) relative to other sites. Advanced T stage predicted worse anxiety (CI -13.0, -2.0, p = 0.03).

CONCLUSIONS:

Surgical approach, management of cervical disease, tumor extent, and site of involvement impacted variable UWQOL symptom areas. Endoscopic resection predicted better pain, appearance, and chewing compared with open. These results may aid in counseling patients regarding potential QOL expectations in their SNM treatment and recovery course.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Neoplasias dos Seios Paranasais Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int Forum Allergy Rhinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Neoplasias dos Seios Paranasais Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int Forum Allergy Rhinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos