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Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.
Lindo, Jorge; Nogueira, Célia; Soares, Rui; Cunha, Nuno; Almeida, Maria Rosário; Rodrigues, Lisa; Coelho, Patrícia; Rodrigues, Francisco; Cunha, Rodrigo A; Gonçalves, Teresa.
Afiliação
  • Lindo J; FMUC-Faculty of Medicine, University Coimbra, 3004-504 Coimbra, Portugal.
  • Nogueira C; CNC-UC-Center for Neuroscience and Cell Biology, University Coimbra, 3004-504 Coimbra, Portugal.
  • Soares R; CIBB-Centre for Innovative Biomedicine and Biotechnology, University Coimbra, 3004-504 Coimbra, Portugal.
  • Cunha N; FMUC-Faculty of Medicine, University Coimbra, 3004-504 Coimbra, Portugal.
  • Almeida MR; CNC-UC-Center for Neuroscience and Cell Biology, University Coimbra, 3004-504 Coimbra, Portugal.
  • Rodrigues L; CIBB-Centre for Innovative Biomedicine and Biotechnology, University Coimbra, 3004-504 Coimbra, Portugal.
  • Coelho P; FMUC-Faculty of Medicine, University Coimbra, 3004-504 Coimbra, Portugal.
  • Rodrigues F; CNC-UC-Center for Neuroscience and Cell Biology, University Coimbra, 3004-504 Coimbra, Portugal.
  • Cunha RA; CIBB-Centre for Innovative Biomedicine and Biotechnology, University Coimbra, 3004-504 Coimbra, Portugal.
  • Gonçalves T; Clinical Pathology Service, Portuguese Oncology Institute of Coimbra, 3004-011 Coimbra, Portugal.
Int J Mol Sci ; 25(11)2024 Jun 02.
Article em En | MEDLINE | ID: mdl-38892324
ABSTRACT
SARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic and genotypic frequencies of a loss-of-function SNP of ADORA2A (rs2298383) and a gain-of-function single nucleotide polymorphism (SNP) of P2RX7 (rs208294) in the severity of SARS-CoV-2-associated infection. Fifty-five individuals were enrolled and categorized according to the severity of the infection. Endpoint genotyping was performed in blood cells to screen for both SNPs. The TT genotype (vs. CT + CC) and the T allele (vs. C allele) of P2RX7 SNP were found to be associated with more severe forms of COVID-19, whereas the association between ADORA2A SNP and the severity of infection was not significantly different. The T allele of P2RX7 SNP was more frequent in people with more than one comorbidity and with cardiovascular conditions and was associated with colorectal cancer. Our findings suggest a more prominent role of P2X7R rather than of A2AR polymorphisms in SARS-CoV-2 infection, although larger population-based studies should be performed to validate our conclusions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Receptores Purinérgicos P2X7 / COVID-19 Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Portugal

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Receptores Purinérgicos P2X7 / COVID-19 Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Portugal