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Glycogen and zinc-enriched ferritin as bioavailable nanoparticulate nutrients released from gastrointestinal digestion of pacific oyster (Crassostrea gigas).
Li, Shiyang; Li, Yangguang; Dou, Mengting; Zhang, Meichao; Zhao, Zifang; Wu, Haohao; Zhu, Suqin; Obadina, Adewale Olusegun.
Afiliação
  • Li S; State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province, 266003, China.
  • Li Y; Institute of Nutrition and Health, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao, Shandong Province, 266021, China.
  • Dou M; State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province, 266003, China.
  • Zhang M; Weihai Institute for Food and Drug Control, Weihai 264299, China.
  • Zhao Z; State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province, 266003, China; Hainan/Haikou Research & Development Center for Biopeptide Engineering, Huayan Collagen Technology Co
  • Wu H; State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province, 266003, China. Electronic address: wuhaohao@ouc.edu.cn.
  • Zhu S; Institute of Nutrition and Health, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao, Shandong Province, 266021, China. Electronic address: zhusuqin@qdu.edu.cn.
  • Obadina AO; Department of Food Science and Technology, Federal University of Agriculture, Abeokuta, Nigeria.
Food Chem ; 457: 140125, 2024 Nov 01.
Article em En | MEDLINE | ID: mdl-38905826
ABSTRACT
Oyster is a low-carbon animal food enriched with protein, glycogen, and trace minerals. Nano-nutrients are increasingly perceived as an unignorable part of foods. Here, simulated gastrointestinal digestion released a considerable amount of nanoparticulate nutrients from raw and cooked oysters. They were identified as glycogen monomers with size of 20-40 nm and their aggregates, as well as 6 nm-sized bare cores of ferritin containing iron and zinc (41, w/w). FITC-labeling and flow cytometry unveiled the efficient uptake of oyster glycogen by polarized Caco-2 cells via macropinocytosis and receptor-mediated endocytosis. Calcein-fluorescence-quenching assay revealed divalent-metal-transporter-1- and macropinocytosis-mediated enterocyte iron absorption from oyster ferritin. Zinquin-fluorescence flow cytometry and ex-vivo mouse ileal loop experiments demonstrated the ready intestinal zinc absorption from oyster ferritin via macropinocytosis, as well as the good resistance of oyster ferritin to phytate's inhibition on zinc absorption. Overall, our results offer a new insight into the digestive and chemical properties of oysters.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zinco / Digestão / Crassostrea / Ferritinas / Glicogênio Limite: Animals / Humans Idioma: En Revista: Food Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zinco / Digestão / Crassostrea / Ferritinas / Glicogênio Limite: Animals / Humans Idioma: En Revista: Food Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China