Association between bisphenol A exposure and cardiometabolic outcomes: A longitudinal approach.
J Hazard Mater
; 476: 135000, 2024 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-38909471
ABSTRACT
Increased cardiometabolic risk is associated with abnormalities in blood biomarkers profile and adiposity measurements. Some substances found in the food matrix and the environment, called endocrine-disrupting chemicals, may impair cardiometabolic health in the early and later stages of life. Bisphenol A (BPA) is a food contaminant that migrates from food contact materials and may act as an endocrine disruptor, negatively affecting human health. The present work aims to longitudinally assess the association between BPA exposure and cardiometabolic outcomes, considering data from Portuguese population-based birth cohort Generation XXI. Blood insulin (0.06stdß; 95 %CI0.03,0.09) and insulin resistance (0.05stdß; 95 %CI0.02,0.08) presented a significant longitudinal association with BPA daily exposure after adjustment for important variables and energy. The same findings were observed for fat mass (0.03stdß; 95 %CI 0.01,0.06) and waist circumference (0.06stdß; 95 %CI0.04,0.08). For z-BMI, a significant cross-sectional (0.03stdß; 95 %CI0.01,0.04) and longitudinal (0.02stdß; 95 %CI0.00,0.04) association was found. This was the first study assessing the association between BPA exposure and health outcomes from childhood to adolescence. We found an association between BPA exposure and increased blood insulin level, insulin resistance, fat mass percentage, waist circumference and z-BMI. Our results point to the need to reduce exposure to BPA in the early stages of life.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Compostos Benzidrílicos
/
Resistência à Insulina
/
Disruptores Endócrinos
Limite:
Adolescent
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Adult
/
Child
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Female
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Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Hazard Mater
Assunto da revista:
SAUDE AMBIENTAL
Ano de publicação:
2024
Tipo de documento:
Article