New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign.
Neuroimaging Clin N Am
; 34(3): 359-373, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38942521
ABSTRACT
Concepts of multiple sclerosis (MS) biology continue to evolve, with observations such as "progression independent of disease activity" challenging traditional phenotypic categorization. Iron-sensitive, susceptibility-based imaging techniques are emerging as highly translatable MR imaging sequences that allow for visualization of at least 2 clinically useful biomarkers the central vein sign and the paramagnetic rim lesion (PRL). Both biomarkers demonstrate high specificity in the discrimination of MS from other mimics and can be seen at 1.5 T and 3 T field strengths. Additionally, PRLs represent a subset of chronic active lesions engaged in "smoldering" compartmentalized inflammation behind an intact blood-brain barrier.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Esclerose Múltipla
Limite:
Humans
Idioma:
En
Revista:
Neuroimaging Clin N Am
Assunto da revista:
DIAGNOSTICO POR IMAGEM
/
NEUROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article