Faecalibaterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors.
Oncoimmunology
; 13(1): 2374954, 2024.
Article
em En
| MEDLINE
| ID: mdl-38957477
ABSTRACT
Gut microbiota impacts responses to immune checkpoint inhibitors (ICI). A high level of Faecalibacterium prausnitzii have been associated with a positive response to ICI in multiple cancer types. Here, based on fecal shotgun metagenomics data, we show in two independent cohorts of patients with non-small cell lung cancer and advanced melanoma that a high level of F. prausnitzii at baseline is positively associated with a better clinical response to ICI. In MCA205 tumor-bearing mice, administration of F. prausnitzii strain EXL01, already in clinical development for Inflammatory Bowel Disease, restores the anti-tumor response to ICI in the context of antibiotic-induced microbiota perturbation at clinical and tumor transcriptomics level. In vitro, EXL01 strain enhances T cell activation in the presence of ICI. Interestingly, oral administration of EXL01 strain did not induce any change in fecal microbiota diversity or composition, suggesting a direct effect on immune cells in the small intestine. F. prausnitzii strain EXL01 will be evaluated as an adjuvant to ICI in multiple cancers in the near future.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microbioma Gastrointestinal
/
Faecalibacterium prausnitzii
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Inibidores de Checkpoint Imunológico
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Oncoimmunology
/
Oncoimmunology (Online)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França