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Histopathological growth pattern and vessel co-option in intrahepatic cholangiocarcinoma.
Li, Zihan; Nguyen Canh, Hiep; Takahashi, Kenta; Le Thanh, Dong; Nguyen Thi, Quynh; Yang, Rui; Yoshimura, Kaori; Sato, Yasunori; Nguyen Thi, Khuyen; Nakata, Hiroki; Ikeda, Hiroko; Kozaka, Kazuto; Kobayashi, Satoshi; Yagi, Shintaro; Harada, Kenichi.
Afiliação
  • Li Z; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Nguyen Canh H; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Takahashi K; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Le Thanh D; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Nguyen Thi Q; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Yang R; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Yoshimura K; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Sato Y; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920-8640, Japan.
  • Nguyen Thi K; Center of Pathology and Molecular Biology, National Cancer Hospital, Hanoi, Vietnam.
  • Nakata H; Department of Clinical Engineering, Faculty of Health Sciences, Komatsu University, Komatsu, Japan.
  • Ikeda H; Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
  • Kozaka K; Department of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa, Japan.
  • Kobayashi S; Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan.
  • Yagi S; Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan.
  • Harada K; Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University, Kanazawa, Japan.
Med Mol Morphol ; 57(3): 200-217, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38960952
ABSTRACT
Intrahepatic cholangiocarcinoma (iCCA) exhibits different blood imaging features and prognosis depending on histology. To clarity histopathological growth patterns (HGPs) and vascularization processes of iCCA, we collected 145 surgical specimens and histologically classified them into large bile duct (LBD) (20 cases), small bile duct (SBD) (54), cholangiolocarcinoma (CLC) (35), combined SBD-CLC (cSBD-CLC) (26), and ductal plate malformation (DPM) (10) (sub)types. According to the invasive pattern at the interface between tumor and adjacent background liver, HGPs were classified into desmoplastic, pushing, and replacing HGPs. Desmoplastic HGP predominated in LBD type (55.5%), while replacing HGP was common in CLC (82.9%) and cSBD-CLC (84.6%) subtypes. Desmoplastic HGP reflected angiogenesis, while replacing HGP showed vessel co-option in addition to angiogenesis. By evaluating microvessel density (MVD) using vascular markers, ELTD1 identified vessel co-option and angiogenesis, and ELTD1-positive MVD at invasive margin in replacing HGP was significantly higher than those in desmoplastic and pushing HGPs. REDD1, an angiogenesis-related marker, demonstrated preferably higher MVD in the tumor center than in other areas. iCCA (sub)types and HGPs were closely related to vessel co-option and immune-related factors (lymphatic vessels, lymphocytes, and neutrophils). In conclusion, HGPs and vascular mechanisms characterize iCCA (sub)types and vessel co-option linked to the immune microenvironment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Ductos Biliares / Colangiocarcinoma / Neovascularização Patológica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Ductos Biliares / Colangiocarcinoma / Neovascularização Patológica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão