Structurally diverse diterpenoids from the leaves of Croton mangelong and their anti-diabetic activity.
Phytochemistry
; 226: 114206, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-38972440
ABSTRACT
Eighteen compounds including eleven previously undescribed diterpenes were isolated from the leaves of Croton mangelong. The structures were determined by HRESIMS, IR, NMR, X-ray diffraction and ECD spectroscopic analysis. All isolates were assayed for their anti-hyperglycemic activities in insulin resistance (IR) 3T3-L1 adipocytes, and compound 4 was tested for its anti-diabetic activity in vivo. Results suggested compound 4 could effectively reduce blood glucose level in diabetic SD rats in a dose of 30 mg/kg.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ratos Sprague-Dawley
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Folhas de Planta
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Croton
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Células 3T3-L1
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Diterpenos
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Hipoglicemiantes
Limite:
Animals
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Iugoslávia